Research and Development Intern

Legend Biotech is seeking an Research & Development Intern as part of the Novel Car Design team based in Somerset, NJ.

Role Overview

This internship will focus on advancing our assessment of in vivo CAR T cell platform. This role will provide hands-on experience in preclinical research and adoptive cell therapy, providing the intern with the opportunity to contribute to cutting-edge experiments and data analysis that drive innovation in our research program.

Key Responsibilities

• Assist in the execution of laboratory experiments, including mammalian cell culture, virus preparation, and immunological and biochemical assays.
• Perform transfections for virus production and assess viral titers using flow cytometry–based and ELISA-based assays.
• Conduct PBMC transduction and perform immunoassays to screen and validate candidates with improved efficacy and safety profiles.
• Perform cytotoxicity assays, immunophenotyping, and cytokine analyses.
• Maintain accurate and detailed records of experimental procedures, data, and observations in laboratory notebooks.
• Analyze experimental data and prepare summaries and reports for team discussions.
• Collaborate with senior scientists and team members to troubleshoot, optimize, and refine experimental protocols.
• Candidate is encouraged to provide technical approaches and troubleshooting strategies, but  all experimental plans, data interpretation, and project-related decisions require review and approval by the manager or designated mentor.
• Decisions regarding project scope, timelines, resource allocation, and overall strategic direction remain under management oversight and are aligned with overall business pipeline priorities. 

Requirements

• Currently enrolled in, or recently graduated from, a Bachelor’s, Master’s program in Biology, Biotechnology, Biochemistry, Immunology, or a related field.
• Preferred to have basic laboratory skills with some hands-on experience in mammalian cell culture (immune cells) and other standard molecular biology techniques, including flow cytometry, qPCR/ddPCR, ELISA, and immunoassays. The ideal candidate would also have some cellular therapy experience.
• Strong analytical and problem-solving, and organizational abilities.
• Excellent written and verbal communication skills.
• Works well independently while thriving in a collaborative team environment.
• Prefer the candidate to have some knowledge of data analysis tools such as Microsoft Office (Excel, Powerpoint), Graphpad Prism, and potentially R and Python. 

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